RAF Typhoon FGR4s have joined forces with French aircraft in a combined operation against an hidden munitions depot in Syrian territory used by the IS group, according to the UK Ministry of Defence.
The facility, located using intelligence, was believed to be housing weapons and explosive materials, the announcement noted, and was located in mountainous terrain just north of the ancient city of Palmyra in the heart of Syria.
"Our fighter planes employed Paveway IV guided bombs to target a series of entry passages leading to the depot... initial indications are that the objective was successfully hit," officials stated.
There was no indication of any civilian impact in the attack on Saturday evening and each participating jet made a safe return, the ministry further stated.
The Typhoon FGR4s were supported by a Voyager tanker plane.
IS - referred to as ISIS - enforced extremist governance over large swathes of both Syria and Iraq before its territorial defeat in 2019.
"This strike shows British leadership, and commitment to stand shoulder to shoulder with our allies, to eliminate any revival of Daesh and their harmful and extremist ideologies in the region," UK Defence Secretary John Healey remarked.
RAF aircraft have carried out overwatch operations over Syrian airspace to "deter any attempted resurgence" of the group after its routing at the battle of Baghuz in 2019, the MoD reported.
"I must thank every member of British forces who took part in this mission for their skill and their bravery," the Defence Secretary commented. "They were among thousands of British personnel on duty over the holidays. This mission, to eliminate terrorist threats who threaten our safety, shows how UK forces are always on standby, continuously, ensuring Britain's security at home and strong abroad."
During December, the American forces conducted what it termed a "large-scale strike" on Islamic State objectives in Syria, following an attack resulted in the deaths of two American soldiers and a civilian interpreter in the Palmyra area.
The United Nations reports Daesh still maintains between 5,000 and 7,000 militants in Iraq and Syria.